Microablative fractional CO2 laser improves dyspareunia related to vulvovaginal atrophy: a pilot study



This pilot study aimed to assess the efficacy in treating sexually active menopausal patients who had dyspareunia related to vulvovaginal atrophy (VVA).

Materials and methods

The intensity of VVA symptoms was recorded for each patient. Patients were administered the Short Form 12 (SF-12) and the female sexual function index (FSFI) to assess quality of life and sexual function, respectively. An objective evaluation of female urogenital health was performed using the Gloria Bachman Vaginal Health Index (VHI).


At 12-week follow-up, the laser treatment was efficacious in improving dyspareunia in 100% of patients included in the study (n = 15). The intensity of dyspareunia significantly decreased from baseline (8.7 ± 1.0) to 12-week follow-up (2.2 ± 1.0; p<0.001). In addition, all other VVA symptoms significantly ameliorated at the same follow-up. Furthermore, after the treatment, a significant improvement in quality of life (QoL) and sexual function were shown.


This pilot study demonstrated that treatment with the microablative fractional CO2 laser of patients with dyspareunia related to VVA was efficacious at 12-week follow-up.

J Endometr Pelvic Pain Disord 2014; 6(3): 150 - 156




Stefano Salvatore, Umberto Leone Roberti Maggiore, Massimo Origoni, Marta Parma, Lavinia Quaranta, Filomena Sileo, Alice Cola, Ilaria Baini, Simone Ferrero, Massimo Candiani, Nicola Zerbinati

Article History


The study was in adherence with the Declaration of Helsinki.
Financial support: No grants or funding have been received for this study.
Conflict of interest: Dr. Stefano Salvatore has had financial relationships (lectures, member of advisory boards and/or consultant) with Pfizer Inc and Astellas. The other authors did not report any potential conflicts of interest.

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  • Obstetrics and Gynaecology Unit, Vita-Salute San Raffaele University and IRRCS San Raffaele Hospital, Milan - Italy
  • Department of Obstetrics and Gynaecology, IRCCS San Martino Hospital and National Institute for Cancer Research, University of Genoa, Genoa - Italy
  • Department of Surgical and Morphological Sciences, University of Insubria, Varese - Italy

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