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A review of the molecular basis for reduced endometrial receptivity in uterine fibroids and polyps

Abstract

The presence of fibroids and endometrial polyps is associated with reduced endometrial receptivity and subsequent fertility outcomes. The following review explores the molecular mechanisms behind reduced endometrial receptivity, with a focus upon homebox genes, basic transcription element binding proteins, transforming growth factor β-3, and bone morphogenetic protein 2. A better understanding of these processes is essential for future targeted therapy.

J Endometr Pelvic Pain Disord 2017; 9(4): 239 - 244

Article Type: REVIEW

DOI:10.5301/jeppd.5000304

Authors

Shagun Narula, Amani Harris, Jim Tsaltas

Article History

Disclosures

Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • Monash University, Melbourne, Victoria - Australia
  • Department of Endoscopic Surgery, Monash Health, Melbourne, Victoria - Australia
  • Melbourne IVF, Melbourne, Victoria - Australia

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