Endometriosis is an estrogen-dependent disorder, and recent studies suggest that progesterone resistance may contribute to the development and pathophysiology of the disorder. Based on this, identification of genetic and molecular perturbations in the endometrium of women with endometriosis is an important step towards understanding the pathogenesis of the disease, and the development of novel treatment and diagnostic strategies.
A systematic literature search in PubMed and Embase was performed, and 118 articles were identified for further screening. Two reviewers performed article screening independently using Covidence, and 16 studies fulfilled the inclusion criteria. The Newcastle-Ottawa Scale was used to assess the quality of these studies.
This review presents data from eutopic endometrial biopsies from women with and without endometriosis. Several biomarkers related to a downregulated progesterone response were identified and discussed in detail.
Our review demonstrates significant results concerning the biomarkers investigated, which may substantiate the theory of progesterone resistance in women with endometriosis. However, further research is necessary to determine their specific role and relevance.
J Endometr Pelvic Pain Disord 2017; 9(4): 245 - 251
Article Type: REVIEW
AuthorsLise Lode, Magnhild Often Sveen, Martin Rudnicki
- • Accepted on 23/08/2017
- • Available online on 29/09/2017
- • Published in print on 24/11/2017
This article is available as full text PDF.
- Lode, Lise [PubMed] [Google Scholar] 1
- Often Sveen, Magnhild [PubMed] [Google Scholar] 1
- Rudnicki, Martin [PubMed] [Google Scholar] 2, * Corresponding Author (firstname.lastname@example.org)
Faculty of Health Sciences, University of Southern Denmark, Odense - Denmark
Department of Obstetrics and Gynecology, Odense University Hospital, Odense - Denmark
Lise Lode and Magnhild Often Sveen contributed equally to this work.