Retinoid metabolism in endometriosis


Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.

J Endometr Pelvic Pain Disord 2017; 9(4): 232 - 238

Article Type: REVIEW



Yiğit Çakıroğlu, Rafael Confino, Mary Ellen Pavone

Article History


Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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  • Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University, Kocaeli - Turkey
  • Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois - USA

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