Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.
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Article Type: REVIEW
Article Subject: Basic sciences
AuthorsYiğit Çakıroğlu, Rafael Confino, Mary Ellen Pavone
- • Accepted on 09/10/2017
- • Available online on 01/11/2017
This article is available as full text PDF.
- Çakıroğlu, Yiğit [PubMed] [Google Scholar] 1
- Confino, Rafael [PubMed] [Google Scholar] 2
- Pavone, Mary Ellen [PubMed] [Google Scholar] 2, * Corresponding Author (firstname.lastname@example.org)
Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University, Kocaeli - Turkey
Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois - USA