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Uterus transplantation: current state and future perspectives

Abstract

Absolute uterine factor infertility (AUFI) has traditionally been regarded as untreatable. Gestational surrogacy (GS) is not permitted in most countries and societies in the world due to ethical, religious or legal reasons. The interest in uterus transplantation (UTx) as a treatment for AUFI started in the 1960s and, after some disappointing results, raised again in the new century, when our and other groups obtained live off-spring after UTx in the mouse, and here we review extensively the results of animal research. In September 2014, the first baby was born after human UTx and this proof-of-concept of UTx as an infertility treatment has been followed by several more births. All cases described in the literature are also reviewed.

The overall evidence suggests that the clinical introduction of UTx as the first available treatment for AUFI has been successful. However, UTx will stay at experimental stage for several years whilst optimizing the procedure and ensuring its safety from a medical and psychological perspective.

J Endometr Pelvic Pain Disord 2017; 9(1): 2 - 8

Article Type: REVIEW

DOI:10.5301/je.5000269

Authors

Mats Brännström, Pernilla Dahm-Kähler

Article History

Disclosures

Financial support: Supported by Jane and Dan Olsson Foundation for Science and the Swedish Research Council.
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg and Stockholm IVF, Gothenburg - Sweden

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